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Stop using isotretinoin and call your doctor at once if you daily have: problems with your vision or hearing; hallucinations, (see or hearing things that are not real thoughts about suicide or hurting yourself; depressed mood, crying spells, changes. I will not fill isotretinoin for any party other than a qualified patient. J Am Acad Dermatol 10:490-496, 1984. This information does not take the place of talking with your doctor about your medical condition or your treatment. In addition, new cases of diabetes have been diagnosed during Accutane therapy, although no causal relationship has been established. If you get once pregnant while taking Accutane, call the ipledge pregnancy registry. See What is the most important information I should know about Accutane (isotretinoin)? Initials: once _ I now allow my doctor _ to begin my treatment with isotretinoin. 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Initials: _ Once I start taking isotretinoin, I agree to stop using isotretinoin and tell my doctor right away if any of the following signs and symptoms of depression or psychosis happen. Overdosage Contraindications overdose The oral LD50 of isotretinoin is greater than 4000 mg/kg in rats and mice ( 600 times the recommended clinical dose.0 mg/kg/day after normalization of the rat dose for total body surface area and. Especially careful consideration must be given to risk/benefit for patients who may be at high risk during Accutane (isotretinoin) therapy (patients with diabetes, obesity, increased daily alcohol intake, lipid metabolism disorder or familial history of lipid metabolism disorder). What are the possible side effects of Accutane (isotretinoin)? These include: Registering prior to distributing isotretinoin and re-registering annually thereafter Distributing only FDA approved isotretinoin product Only shipping isotretinoin to wholesalers registered in the ipledge program with prior written consent from the manufacturer or pharmacies licensed. Tell your doctor if you get: back pain joint daily pain broken bone. Hyperostosis may require a longer time frame to appear. X X, description, isotretinoin, a retinoid, is available as Accutane (isotretinoin) in 10-mg, 20-mg and 40-mg soft gelatin capsules for oral administration. I will obtain Accutane product only from ipledge registered wholesalers. Medication guide accutane (ACK-U-tane) (isotretinoin capsules) Read the Medication Guide that comes with Accutane (isotretinoin) before you start taking it and each time you get a prescription. Each month of therapy, patients must have a negative result from a urine or serum pregnancy test. 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